diff --git a/README.md b/README.md
index f67d346b75..feaa550ef4 100644
--- a/README.md
+++ b/README.md
@@ -100,12 +100,6 @@ compileOptions {
 }
 ```
 
-#### 3. Enable multidex
-
-If your Gradle `minSdkVersion` is 20 or lower, you should
-[enable multidex](https://developer.android.com/studio/build/multidex) in order
-to prevent build errors.
-
 ### Locally
 
 Cloning the repository and depending on the modules locally is required when
diff --git a/common_library_config.gradle b/common_library_config.gradle
index da66c47e47..c54e686f53 100644
--- a/common_library_config.gradle
+++ b/common_library_config.gradle
@@ -27,7 +27,6 @@ android {
         aarMetadata {
             minCompileSdk = project.ext.compileSdkVersion
         }
-        multiDexEnabled true
     }
 
     compileOptions {
@@ -42,7 +41,3 @@ android {
         unitTests.includeAndroidResources true
     }
 }
-
-dependencies {
-    androidTestImplementation 'androidx.multidex:multidex:' + androidxMultidexVersion
-}
diff --git a/constants.gradle b/constants.gradle
index aab5aa5e61..81b8b9f504 100644
--- a/constants.gradle
+++ b/constants.gradle
@@ -47,7 +47,6 @@ project.ext {
     androidxExifInterfaceVersion = '1.3.6'
     androidxLifecycleVersion = '2.6.0'
     androidxMediaVersion = '1.7.0'
-    androidxMultidexVersion = '2.0.1'
     androidxRecyclerViewVersion = '1.3.0'
     androidxMaterialVersion = '1.8.0'
     androidxTestCoreVersion = '1.5.0'
diff --git a/demos/cast/build.gradle b/demos/cast/build.gradle
index de067a5708..a60081ea3a 100644
--- a/demos/cast/build.gradle
+++ b/demos/cast/build.gradle
@@ -29,7 +29,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -62,7 +61,6 @@ dependencies {
     implementation project(modulePrefix + 'lib-ui')
     implementation project(modulePrefix + 'lib-cast')
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'androidx.recyclerview:recyclerview:' + androidxRecyclerViewVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
 }
diff --git a/demos/cast/src/main/AndroidManifest.xml b/demos/cast/src/main/AndroidManifest.xml
index b6a9b56eac..e852ca39fa 100644
--- a/demos/cast/src/main/AndroidManifest.xml
+++ b/demos/cast/src/main/AndroidManifest.xml
@@ -23,7 +23,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:label="@string/application_name"
       android:icon="@mipmap/ic_launcher"
       android:largeHeap="true"
diff --git a/demos/cast/src/main/java/androidx/media3/demo/cast/DemoApplication.java b/demos/cast/src/main/java/androidx/media3/demo/cast/DemoApplication.java
deleted file mode 100644
index a06b8d1b39..0000000000
--- a/demos/cast/src/main/java/androidx/media3/demo/cast/DemoApplication.java
+++ /dev/null
@@ -1,23 +0,0 @@
-/*
- * Copyright 2020 The Android Open Source Project
- *
- * Licensed under the Apache License, Version 2.0 (the "License");
- * you may not use this file except in compliance with the License.
- * You may obtain a copy of the License at
- *
- *      http://www.apache.org/licenses/LICENSE-2.0
- *
- * Unless required by applicable law or agreed to in writing, software
- * distributed under the License is distributed on an "AS IS" BASIS,
- * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
- * See the License for the specific language governing permissions and
- * limitations under the License.
- */
-package androidx.media3.demo.cast;
-
-import androidx.multidex.MultiDexApplication;
-
-// Note: Multidex is enabled in code not AndroidManifest.xml because the internal build system
-// doesn't dejetify MultiDexApplication in AndroidManifest.xml.
-/** Application for multidex support. */
-public final class DemoApplication extends MultiDexApplication {}
diff --git a/demos/composition/build.gradle b/demos/composition/build.gradle
index 9b11ece9e3..a421b8a386 100644
--- a/demos/composition/build.gradle
+++ b/demos/composition/build.gradle
@@ -31,7 +31,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -58,6 +57,5 @@ dependencies {
     implementation project(modulePrefix + 'lib-transformer')
     implementation project(modulePrefix + 'lib-ui')
     implementation 'androidx.annotation:annotation:' + androidxAnnotationVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     compileOnly 'org.checkerframework:checker-qual:' + checkerframeworkVersion
 }
diff --git a/demos/gl/build.gradle b/demos/gl/build.gradle
index 5a19c6e796..7e28ec0e00 100644
--- a/demos/gl/build.gradle
+++ b/demos/gl/build.gradle
@@ -29,7 +29,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -55,6 +54,5 @@ dependencies {
     implementation project(modulePrefix + 'lib-exoplayer-smoothstreaming')
     implementation project(modulePrefix + 'lib-ui')
     implementation 'androidx.annotation:annotation:' + androidxAnnotationVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     compileOnly 'org.checkerframework:checker-qual:' + checkerframeworkVersion
 }
diff --git a/demos/gl/src/main/AndroidManifest.xml b/demos/gl/src/main/AndroidManifest.xml
index d44f8ea343..d4d79a7053 100644
--- a/demos/gl/src/main/AndroidManifest.xml
+++ b/demos/gl/src/main/AndroidManifest.xml
@@ -22,7 +22,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       android:icon="@mipmap/ic_launcher"
       android:label="@string/application_name">
diff --git a/demos/main/build.gradle b/demos/main/build.gradle
index 6a49adf169..a5c3852faa 100644
--- a/demos/main/build.gradle
+++ b/demos/main/build.gradle
@@ -31,7 +31,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -75,7 +74,6 @@ dependencies {
     compileOnly 'org.checkerframework:checker-qual:' + checkerframeworkVersion
     implementation 'androidx.annotation:annotation:' + androidxAnnotationVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation project(modulePrefix + 'lib-exoplayer')
     implementation project(modulePrefix + 'lib-exoplayer-dash')
diff --git a/demos/main/src/main/AndroidManifest.xml b/demos/main/src/main/AndroidManifest.xml
index da13a42ca4..1a3dff3102 100644
--- a/demos/main/src/main/AndroidManifest.xml
+++ b/demos/main/src/main/AndroidManifest.xml
@@ -40,7 +40,6 @@
       android:largeHeap="true"
       android:allowBackup="false"
       android:supportsRtl="true"
-      android:name="androidx.multidex.MultiDexApplication"
       tools:targetApi="29">
 
     <activity android:name=".SampleChooserActivity"
diff --git a/demos/session/build.gradle b/demos/session/build.gradle
index bd2c1dd7eb..496f7f4e49 100644
--- a/demos/session/build.gradle
+++ b/demos/session/build.gradle
@@ -34,7 +34,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -65,7 +64,6 @@ dependencies {
     implementation 'androidx.lifecycle:lifecycle-common:' + androidxLifecycleVersion
     implementation 'androidx.lifecycle:lifecycle-runtime-ktx:' + androidxLifecycleVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation 'org.jetbrains.kotlinx:kotlinx-coroutines-guava:' + kotlinxCoroutinesVersion
     implementation project(modulePrefix + 'lib-ui')
diff --git a/demos/session/src/main/AndroidManifest.xml b/demos/session/src/main/AndroidManifest.xml
index d902b7f414..95758b0efb 100644
--- a/demos/session/src/main/AndroidManifest.xml
+++ b/demos/session/src/main/AndroidManifest.xml
@@ -23,7 +23,6 @@
   <uses-permission android:name="android.permission.FOREGROUND_SERVICE_MEDIA_PLAYBACK" />
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       android:icon="@mipmap/ic_launcher"
       android:label="@string/app_name"
diff --git a/demos/session_automotive/build.gradle b/demos/session_automotive/build.gradle
index d745bfeedb..e909093028 100644
--- a/demos/session_automotive/build.gradle
+++ b/demos/session_automotive/build.gradle
@@ -34,7 +34,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.automotiveMinSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -60,7 +59,6 @@ android {
 dependencies {
     implementation 'androidx.core:core-ktx:' + androidxCoreVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation project(modulePrefix + 'lib-session')
     implementation project(modulePrefix + 'demo-session-service')
diff --git a/demos/session_automotive/src/main/AndroidManifest.xml b/demos/session_automotive/src/main/AndroidManifest.xml
index a35fbb4e2e..514547fc9d 100644
--- a/demos/session_automotive/src/main/AndroidManifest.xml
+++ b/demos/session_automotive/src/main/AndroidManifest.xml
@@ -39,7 +39,6 @@
     android:resource="@xml/automotive_app_desc"/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       android:taskAffinity=""
       android:appCategory="audio"
diff --git a/demos/session_service/build.gradle b/demos/session_service/build.gradle
index 7f03ad105b..6137e86524 100644
--- a/demos/session_service/build.gradle
+++ b/demos/session_service/build.gradle
@@ -33,7 +33,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -54,7 +53,6 @@ android {
 dependencies {
     implementation 'androidx.core:core-ktx:' + androidxCoreVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation project(modulePrefix + 'lib-exoplayer')
     implementation project(modulePrefix + 'lib-exoplayer-dash')
     implementation project(modulePrefix + 'lib-exoplayer-hls')
diff --git a/demos/shortform/build.gradle b/demos/shortform/build.gradle
index 47ad2cd736..148d68524e 100644
--- a/demos/shortform/build.gradle
+++ b/demos/shortform/build.gradle
@@ -34,7 +34,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -80,7 +79,6 @@ dependencies {
 
     implementation 'androidx.core:core-ktx:' + androidxCoreVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation project(modulePrefix + 'lib-exoplayer')
     implementation project(modulePrefix + 'lib-exoplayer-dash')
diff --git a/demos/shortform/src/main/AndroidManifest.xml b/demos/shortform/src/main/AndroidManifest.xml
index a1d03af062..e76ab36c00 100644
--- a/demos/shortform/src/main/AndroidManifest.xml
+++ b/demos/shortform/src/main/AndroidManifest.xml
@@ -21,7 +21,6 @@
     android:allowBackup="false"
     android:icon="@mipmap/ic_launcher"
     android:label="@string/app_name"
-    android:name="androidx.multidex.MultiDexApplication"
     android:theme="@style/Theme.MaterialComponents.DayNight.NoActionBar"
     android:taskAffinity=""
     tools:replace="android:name">
diff --git a/demos/transformer/build.gradle b/demos/transformer/build.gradle
index 63f27f3a78..b0b01c20b2 100644
--- a/demos/transformer/build.gradle
+++ b/demos/transformer/build.gradle
@@ -31,7 +31,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
     }
 
     buildTypes {
@@ -77,7 +76,6 @@ dependencies {
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
     implementation 'androidx.constraintlayout:constraintlayout:' + androidxConstraintLayoutVersion
     implementation 'androidx.recyclerview:recyclerview:' + androidxRecyclerViewVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation project(modulePrefix + 'lib-effect')
     implementation project(modulePrefix + 'lib-exoplayer')
diff --git a/libraries/datasource/src/androidTest/AndroidManifest.xml b/libraries/datasource/src/androidTest/AndroidManifest.xml
index afcbb337b5..32373d1c2a 100644
--- a/libraries/datasource/src/androidTest/AndroidManifest.xml
+++ b/libraries/datasource/src/androidTest/AndroidManifest.xml
@@ -23,7 +23,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       android:usesCleartextTraffic="true"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode">
diff --git a/libraries/datasource_cronet/src/androidTest/AndroidManifest.xml b/libraries/datasource_cronet/src/androidTest/AndroidManifest.xml
index fd7a6dcc79..7da3a987c1 100644
--- a/libraries/datasource_cronet/src/androidTest/AndroidManifest.xml
+++ b/libraries/datasource_cronet/src/androidTest/AndroidManifest.xml
@@ -23,7 +23,6 @@
   <uses-sdk/>
 
   <application
-    android:name="androidx.multidex.MultiDexApplication"
     android:allowBackup="false"
     android:usesCleartextTraffic="true"
     tools:ignore="MissingApplicationIcon,HardcodedDebugMode"/>
diff --git a/libraries/decoder_flac/src/androidTest/AndroidManifest.xml b/libraries/decoder_flac/src/androidTest/AndroidManifest.xml
index d28b481540..1451696625 100644
--- a/libraries/decoder_flac/src/androidTest/AndroidManifest.xml
+++ b/libraries/decoder_flac/src/androidTest/AndroidManifest.xml
@@ -22,7 +22,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"/>
 
diff --git a/libraries/decoder_opus/src/androidTest/AndroidManifest.xml b/libraries/decoder_opus/src/androidTest/AndroidManifest.xml
index ab27436543..b6ed01f150 100644
--- a/libraries/decoder_opus/src/androidTest/AndroidManifest.xml
+++ b/libraries/decoder_opus/src/androidTest/AndroidManifest.xml
@@ -22,7 +22,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"/>
 
diff --git a/libraries/decoder_vp9/src/androidTest/AndroidManifest.xml b/libraries/decoder_vp9/src/androidTest/AndroidManifest.xml
index b22a45dedd..818d5196fc 100644
--- a/libraries/decoder_vp9/src/androidTest/AndroidManifest.xml
+++ b/libraries/decoder_vp9/src/androidTest/AndroidManifest.xml
@@ -22,7 +22,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"/>
 
diff --git a/libraries/exoplayer/src/androidTest/AndroidManifest.xml b/libraries/exoplayer/src/androidTest/AndroidManifest.xml
index cee0ce28ad..b1fb1cf643 100644
--- a/libraries/exoplayer/src/androidTest/AndroidManifest.xml
+++ b/libraries/exoplayer/src/androidTest/AndroidManifest.xml
@@ -23,7 +23,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"
       android:usesCleartextTraffic="true"/>
diff --git a/libraries/exoplayer_ima/src/androidTest/AndroidManifest.xml b/libraries/exoplayer_ima/src/androidTest/AndroidManifest.xml
index 986dce0394..0b0db6b46a 100644
--- a/libraries/exoplayer_ima/src/androidTest/AndroidManifest.xml
+++ b/libraries/exoplayer_ima/src/androidTest/AndroidManifest.xml
@@ -24,7 +24,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode">
     <activity android:name="androidx.media3.test.utils.HostActivity"
diff --git a/libraries/extractor/src/androidTest/AndroidManifest.xml b/libraries/extractor/src/androidTest/AndroidManifest.xml
index 6339266515..d5e5195cd3 100644
--- a/libraries/extractor/src/androidTest/AndroidManifest.xml
+++ b/libraries/extractor/src/androidTest/AndroidManifest.xml
@@ -21,7 +21,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"
       android:usesCleartextTraffic="true"/>
diff --git a/libraries/test_exoplayer_playback/src/androidTest/AndroidManifest.xml b/libraries/test_exoplayer_playback/src/androidTest/AndroidManifest.xml
index 2374319ed6..a0d2fd0cfe 100644
--- a/libraries/test_exoplayer_playback/src/androidTest/AndroidManifest.xml
+++ b/libraries/test_exoplayer_playback/src/androidTest/AndroidManifest.xml
@@ -24,7 +24,6 @@
   <uses-sdk/>
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode">
     <activity android:name="androidx.media3.test.utils.HostActivity"
diff --git a/libraries/test_session_current/build.gradle b/libraries/test_session_current/build.gradle
index 66e9778bc9..9feae32e90 100644
--- a/libraries/test_session_current/build.gradle
+++ b/libraries/test_session_current/build.gradle
@@ -40,7 +40,6 @@ dependencies {
     implementation project(modulePrefix + 'test-session-common')
     implementation project(modulePrefix + 'test-data')
     implementation 'androidx.media:media:' + androidxMediaVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'androidx.test:core:' + androidxTestCoreVersion
     implementation project(modulePrefix + 'test-data')
     androidTestImplementation project(modulePrefix + 'lib-exoplayer')
diff --git a/libraries/test_session_current/src/androidTest/AndroidManifest.xml b/libraries/test_session_current/src/androidTest/AndroidManifest.xml
index e2263fbec1..ffdbb11f5b 100644
--- a/libraries/test_session_current/src/androidTest/AndroidManifest.xml
+++ b/libraries/test_session_current/src/androidTest/AndroidManifest.xml
@@ -19,7 +19,6 @@
   <uses-sdk />
 
   <application
-      android:name="androidx.multidex.MultiDexApplication"
       android:allowBackup="false"
       tools:ignore="MissingApplicationIcon,HardcodedDebugMode"
       android:usesCleartextTraffic="true" >
diff --git a/libraries/test_session_current/src/main/AndroidManifest.xml b/libraries/test_session_current/src/main/AndroidManifest.xml
index 4cada70076..c6de7e1fed 100644
--- a/libraries/test_session_current/src/main/AndroidManifest.xml
+++ b/libraries/test_session_current/src/main/AndroidManifest.xml
@@ -24,9 +24,7 @@
     <package android:name="androidx.media3.test.session.test" />
   </queries>
 
-  <application
-      android:name="androidx.multidex.MultiDexApplication"
-      android:allowBackup="false">
+  <application android:allowBackup="false">
     <activity android:name="androidx.media3.test.session.common.SurfaceActivity"
         android:exported="false" />
 
diff --git a/missing_aar_type_workaround.gradle b/missing_aar_type_workaround.gradle
index 8d51b28060..be03422e2d 100644
--- a/missing_aar_type_workaround.gradle
+++ b/missing_aar_type_workaround.gradle
@@ -41,7 +41,6 @@ def addMissingAarTypeToXml(xml) {
         "androidx.leanback:leanback",
         "androidx.media:media",
         "androidx.media2:media2-session",
-        "androidx.multidex:multidex",
         "androidx.recyclerview:recyclerview",
         "androidx.test:core",
         "androidx.test.ext:junit",
diff --git a/testapps/controller/build.gradle b/testapps/controller/build.gradle
index c43453f7ed..680cd90bec 100644
--- a/testapps/controller/build.gradle
+++ b/testapps/controller/build.gradle
@@ -34,7 +34,6 @@ android {
         versionCode project.ext.releaseVersionCode
         minSdkVersion project.ext.minSdkVersion
         targetSdkVersion project.ext.appTargetSdkVersion
-        multiDexEnabled true
         vectorDrawables.useSupportLibrary = true
     }
 
@@ -62,7 +61,6 @@ android {
 dependencies {
     implementation 'androidx.core:core-ktx:' + androidxCoreVersion
     implementation 'androidx.appcompat:appcompat:' + androidxAppCompatVersion
-    implementation 'androidx.multidex:multidex:' + androidxMultidexVersion
     implementation 'com.google.android.material:material:' + androidxMaterialVersion
     implementation 'androidx.media:media:' + androidxMediaVersion
     implementation project(modulePrefix + 'lib-session')