diff --git a/library/core/src/main/java/com/google/android/exoplayer2/mediacodec/MediaCodecRenderer.java b/library/core/src/main/java/com/google/android/exoplayer2/mediacodec/MediaCodecRenderer.java
index 2bc8d2fbdf..0f6bbb3120 100644
--- a/library/core/src/main/java/com/google/android/exoplayer2/mediacodec/MediaCodecRenderer.java
+++ b/library/core/src/main/java/com/google/android/exoplayer2/mediacodec/MediaCodecRenderer.java
@@ -2092,6 +2092,11 @@ public abstract class MediaCodecRenderer extends BaseRenderer {
 
     // Note: Both oldSession and newSession are non-null, and they are different sessions.
 
+    if (!newSession.getSchemeUuid().equals(oldSession.getSchemeUuid())) {
+      // MediaCrypto.setMediaDrmSession is unable to switch between DRM schemes.
+      return true;
+    }
+
     if (Util.SDK_INT < 23) {
       // MediaCrypto.setMediaDrmSession is only available from API level 23, so re-initialization is
       // required to switch to newSession on older API levels.